Zypadhera(TM) Receives Positive Opinion from the European Committee for Medicinal Products for Human Use (CHMP) for Maintenance

Olanzapine long-acting injection is an investigational formulation that combines
olanzapine, an atypical antipsychotic, with pamoic acid resulting in a salt that
sustains the delivery of olanzapine for a period of up to four weeks.
Long-acting injectables have been associated with improved treatment for
patients who struggle with adherence to oral medications.(i) …

Metabolics, Pharmacokinetics

Existing Anti-obesity Drugs May Be Effective Against Flu, Hepatitis And HIV

Extensive clinical testing would be needed to draw conclusions about the safety
of TOFA and C75, or similar compounds, as antiviral treatment. That said, the
team took an early look at toxicity, exposing uninfected fibroblasts to C75 or
TOFA for 96 hours. They found that the drugs blocked HCMV replication without
causing cell toxicity or self-destruction (apoptosis). …

Pharmacokinetics, Toxicology

CAUTION: Concomitant Administration of Clozapine and Lorazepam (Clozaril and Ativan)

Because even the most benign of side effects has the potential of
becoming fatal in certain circumstances if left unaddressed, it is
imperative for patients, clinicians, pharmacists, and all health care
professionals to be aware of adverse reactions and possible complica
tions of clozapine therapy to prevent significant morbidity and
mortality. …

Pharmacogenetics, Pharmacokinetics

Clozaril Side Effects & Drug Interactions Associated with Discontinuation of Treatment

Clozapine is a substrate for many CYP450 isozymes, in particular 1A2, 2D6, and
3A4. The risk of metabolic interactions caused by an effect on an individual
isoform is therefore minimized. Nevertheless, caution should be used in patients
receiving concomitant treatment with other drugs that are either inhibitors or
inducers of these enzymes. …