Clozapine is a substrate for many CYP450 isozymes, in particular 1A2, 2D6, and
3A4. The risk of metabolic interactions caused by an effect on an individual
isoform is therefore minimized. Nevertheless, caution should be used in patients
receiving concomitant treatment with other drugs that are either inhibitors or
inducers of these enzymes. …
It is well recognized that most medications exhibit wide interpatient
variability in their efficacy and toxicity. For many medications, these
interindividual differences are due in part to polymorphisms in genes encoding
drug metabolizing enzymes, drug transporters, and/or drug targets (e.g.,
receptors, enzymes). …
some differences in drug efficacy response, and some toxicities, are based on
variability in exposure or in pharmacodynamic response, caused by genetic
differences …
The polymorphic forms of the CYP450s are responsible for the
development of a significant number of adverse drug reactions and may
also contribute to drug response. …
Some say the fact that a few quick medication-monitoring visits pay much better
than a longer psychotherapy session conducted in the same amount of time could
be the reason for the switch …
A truly Revolutionary approach to healing cancer. This is a non-invasive,
magnificently simple CURE using Sodium Bicarbonate or Baking Soda. The best
anti-fungal around. …
A world-renowned
Harvard child psychiatrist whose work has helped fuel an explosion
in the use of powerful antipsychotic medicines in children earned at least $1.6
million in consulting fees from drug makers from 2000 to 2007 but for years did
not report much of this income to university officials, according to information
given Congressional investigators. …
John Burklow, a spokesman for the National Institutes of Health,
said: “If
there have been violations of N.I.H. policy – and if
research integrity has
been compromised – we will take all the
appropriate action within our power
to hold those responsible
accountable. This would be completely unacceptable
behavior, and
N.I.H. will not tolerate it.”
…
The chemical’s major advantage, according to the researchers, is its apparent
non-toxicity.
…
Drink water. Pure, fresh spring water. Not tap water, not bottled water filled
with plastics. Find and drink pure water from the Earth, and you will be doing
your part to help sustain the potential for human life on this planet for
generations to come. You’ll also be saving countless cows from abusive
exploitation by commercial dairy ranches, many of which now laughingly claim to
be “organic.” See the Organic Consumers Association (
href=”http://www.organicconsumers.org/” target=_blank>
color=#3366cc>www.OrganicConsumers.org) to learn more about the false
organic cow’s milk producers. While there are a few, smaller …