1 ,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ), which is the biologically active form
of vitamin D, has anti-inflammatory effects and can prevent experimental
Parkinson’s disease (PD). …
We hypothesize, based upon several lines of evidence, that documented
chronically inadequate vitamin D intake in the United States, particularly in
the northern states and particularly in the elderly, is a significant factor in
the pathogenesis of PD. …
Researchers hypothesize, based upon several lines of evidence, that documented
chronically inadequate vitamin D intake in the United States,
particularly in the northern states and particularly in the elderly, is a
significant factor in the causes of Parkinson’s disease. …
Do they really think readers are so stupid as to believe sunshine exposure
causes Parkinson’s disease? They’re apparently willing to print the false
headlines and find out. …
eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are prevalent
in fish and fish oils, have been studied in thousands of investigations. A
consistent body of evidence has been elaborated in various types of
investigations, ultimately demonstrating reduction in total mortality,
cardiovascular mortality, and morbidity by ingestion of roughly 1 g/d of EPA
plus DHA. …
A current theory proposes that a defect in methylation processes is central to
the biochemical basis of the neuropsychiatry of these vitamin deficiencies. …
Some researchers question whether these non-cyanocobalamin supplements are
stable in their oral form. For this reason, much larger amounts are typically
used with hope that at least some are absorbed intact. One study suggests that
once absorbed, methylcobalamin may be retained in the body better than
cyanocobalamin.30
…
The advantage using hydroxocobalamin is the lack of adverse effects seen with
the nitrites such as methemoglobinemia and hypotension. It works by exchanging
the hydroxy group for cyanide to form the non-toxic cyanocobalamin (vitamin
B12). …
The hydroxocobalamin neutralizes cyanide by fixing it to form cyanocobalamin
(vitamin B12) which is excreted in the urine. It does not have the problem of
reducing the blood’s capacity to carry oxygen as in the case of nitrite
administration. Hydroxocobalamin is red in color and will turn the mucous
membranes, skin, and urine red, which could interfere with clinical laboratory
tests which depend on color. …
The antitode used in Europe is hydroxocobalamin, a precursor to Vitamin B-12.
The drug is given intravenously and neutralizes cyanide to form cyanocobalamin,
Vitamin B-12, which the body expells by urination. …