Month: October 2008

Nutriceutical, Toxicology

Hydrogen Cyanide Poisoning from Inhalation of Smoke Produced in Fires (Aristatek, Inc)

The hydroxocobalamin neutralizes cyanide by fixing it to form cyanocobalamin
(vitamin B12) which is excreted in the urine. It does not have the problem of
reducing the blood’s capacity to carry oxygen as in the case of nitrite
administration. Hydroxocobalamin is red in color and will turn the mucous
membranes, skin, and urine red, which could interfere with clinical laboratory
tests which depend on color. …

Pharmacokinetics

Zypadhera(TM) Receives Positive Opinion from the European Committee for Medicinal Products for Human Use (CHMP) for Maintenance

Olanzapine long-acting injection is an investigational formulation that combines
olanzapine, an atypical antipsychotic, with pamoic acid resulting in a salt that
sustains the delivery of olanzapine for a period of up to four weeks.
Long-acting injectables have been associated with improved treatment for
patients who struggle with adherence to oral medications.(i) …

Metabolics, Pharmacokinetics

Existing Anti-obesity Drugs May Be Effective Against Flu, Hepatitis And HIV

Extensive clinical testing would be needed to draw conclusions about the safety
of TOFA and C75, or similar compounds, as antiviral treatment. That said, the
team took an early look at toxicity, exposing uninfected fibroblasts to C75 or
TOFA for 96 hours. They found that the drugs blocked HCMV replication without
causing cell toxicity or self-destruction (apoptosis). …