Atypical Antipsychotics and Vitamin C integration
If the building blocks of protien which are amino acids, their coenzymes which are vitamins and the cofactors of vitamins which are minerals actually comprise the very neurotransmitters that our brains squirt around; and, if essential fatty acids like omega 3 and omega 6 make up 60 percent of the brain! Then doesn't it rationalize out that they may be used to prevent, treat, and reverse mental disorders? Or, help to reduce the dosage of medications and reduce side effects?
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G. N. Dakhale1, S. D. Khanzode1, 2 
, S. S. Khanzode3 and A. Saoji4
| (1) | Department of Pharmacology, Government Medical College, Nagpur, India |
| (2) | 46, S.E. Rly Colony (1), Venkatesh Apartment, Pratap Nagar, Nagpur, Maharashtra, 440 022, India |
| (3) | Biochemist in Medicine, Government Medical College, Nagpur, India |
| (4) | Department of Psychiatry, Government Medical College, Nagpur, India |
Received: 3 February 2005 Accepted: 27 June 2005 Published online: 13 August 2005
Abstract
Method Forty schizophrenic patients participated in a prospective, double-blind, placebo-controlled, noncrossover, 8-week study. The patients with schizophrenia were divided randomly into placebo and vitamin C group of 20 each. Serum MDA and plasma ascorbic acid were estimated by methods of Nischal and Aye, respectively.
Result Increased serum MDA and decreased plasma ascorbic acid levels were found in schizophrenic patients. These levels were reversed significantly after treatment with vitamin C along with atypical antipsychotics compared to placebo with atypical antipsychotics. BPRS change scores at 8 weeks improved statistically significant with vitamin C as compared to placebo.
Keywords Schizophrenia - Vitamin C - Atypical antipsychotics - Oxidative stress - BPRS score
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